|Alma mater||University of Pune|
Indian Institute of Technology, Kanpur
Carnegie Mellon University
|Institutions||Indian Institute of Science|
|Doctoral advisor||Aksel A. Bothner-By|
Padmanabhan Balaram is an Indian biochemist and a former director of the Indian Institute of Science in Bangalore, India. He is a recipient of the third highest Indian civilian honour of Padma Bhushan (2014) as well as the TWAS Prize (1994). He has been conferred the 2021 R. Bruce Merrifield Award by the American Peptide Society.
Balaram received his bachelor's degree in Chemistry from Fergusson College, University of Pune followed by a master's degree from the Indian Institute of Technology, Kanpur and his PhD degree from Carnegie Mellon University with Aksel A. Bothner-By. After a postdoctoral stint at Harvard University with Nobel laureate Robert Burns Woodward, he returned to the Indian Institute of Science, where he has been ever since as a faculty member in the Molecular Biophysics Unit. He presently holds a Chaired Professorship at the National Center for Biological Sciences, Bangalore. During his PhD, Balaram studied the use of negative Nuclear Overhauser effect signals as probes of macromolecular conformations. As a postdoc with Woodword, Balaram worked on the synthesis of the antibiotic erythromycin.
Balaram's main area of research has been the investigation of the structure, conformation, and biological activity of designed and natural peptides. To do this, he has extensively used techniques such as Nuclear Magnetic Resonance spectroscopy, Infrared spectroscopy, and Circular Dichroism, along with X-ray crystallography. He has been a major contributor to the evaluation of factors influencing the folding and conformations of designed peptides, and has investigated structural elements playing a key role in the formation of secondary structural motifs such as helices, beta turns, and sheets. Along with Isabella Karle, a frequent collaborator, he has also pioneered the use of alpha-amino isobutyric acid to induce and retain helicity and constrain peptide conformations.
Prof. Balaram is an exceptional teacher and his course on spectroscopy was very popular with students at the Indian Institute of Science. His unique teaching methodology combined with the clarity and lucidity of his approach enabled a generation of scientists to emerge with a clear understanding on the fundamentals of spectroscopy.
- Receives Padma Bhushan
- Prof. P. Balaram lab Webpage at IISc Retrieved 16 July 2012
- "Padma Awards". Retrieved 17 April 2016.
- "Prizes and Awards". The World Academy of Sciences. 2016.
- "Merrifield Award – American Peptide Society". Retrieved 11 March 2021.
- National Knowledge Commission member P. Balaram Archived 17 October 2007 at the Wayback Machine Retrieved 16 July 2012
- Interview with Prof. P. Balaram, Department of Chemistry IIT Delhi CHEMCOS Journal of The Chemical Society, IIT Delhi. Issue IV :June 2009. Retrieved 16 July 2012
- Prof. P. Balaram’s lab Retrieved 16 July 2012
- "Indian Fellow". INSA. 30 October 2017. Retrieved 30 October 2017.
- Current Science Editorial Board Retrieved 16 July 2012
- Srinivasan, Bharath (27 September 2020). "Words of advice: teaching enzyme kinetics". The FEBS Journal. doi:10.1111/febs.15537. ISSN 1742-464X.